A nurse should clarify which prescription regarding hydrochlorothiazide?

In the context of prescribing hydrochlorothiazide, the appropriate dosages typically range from 12.5 mg to 50 mg once daily. While 25 mg once a day and 12.5 mg once daily are standard practices, the specific prescription of 50 mg twice daily is unusually high for most cases and may exceed recommended dosages unless there are extenuating circumstances such as severe hypertension or renal issues.

Hydrochlorothiazide is a thiazide diuretic commonly used in the management of hypertension and edema, with a usual maximum daily dose being around 50 mg. Dosing it at 75 mg per day, especially in two divided doses, increases the risk of adverse effects without substantial benefit. Therefore, it's prudent for the nurse to clarify this prescription to ensure patient safety and adherence to established guidelines.